In 1864 D.H. Cussons read a letter entitled the "French Pharmacy" to the Leeds Chemists' Association based on his personal experience of holding the post of manager of the English department of a pharmacy in Paris.

D. H Cussons & Company is believed to have been established in approximately 1866 in Southport, Lancashire, originally for the business of chemistry.

In 1871 D.H. Cussons & Co. was located at 50 Hoghton st. Southport

In 1873 D.H. Cussons & Co. was recorded as a dealer in photographic goods as part of a in a law suit. Where D.H. Cussons & Co. was sued by a person called Harman over a carte-de-viste that Cusson's requested to be enlarged and coloured. Cussons alleged the work was poor.

In approximately 1876, D.H. Cussons & Co. published the "Photographers Almanac", which turned out to be a popular reference book.

In 1878 D.H. Cussons & Co. was located Birkdale Park, Southport. At this time D.H. Cusson's in association with A. Cowan patented a "photographic camera shutter", no. 2608 dated June 29, 1878. This was believed to be one of the first if not the first electro-magnetic shutter, being "open and closed by an electromagnet".

In 1882, D. H Cussons & Company was described as manufacturing chemists located 79, Bold Street, Liverpool and also at Southport in the business of photographic requisites manufactured and sold by them. They sold Liverpool Bromo-Gelatine Dry plates, the Liverpool instantaneous shutter, etc.. They supplied four descriptions of outfits, namely "The American set" for taking 4 1/4 x 3 1/4 inch and 5 x 4 inch exposures priced at L4 10s. "The artist set" for negatives 4 1/4 x 3 1/4 inch (carte de visit size), at L6 10s. the "Tourist's Set" for negatives 6 12 x 4 3/4 inches (cabinet size), at L9 10s. Lastly the "military Officers Set" for negatives 7 1/4 x 4 1/4 inches at L14 10s. It was noted that they supplied Extra Rapid plates, by order, to the staff of Sir Garnet Wolseley, for the Egyptian campaign. They released a catalogue entitled "Notes for the Amatuer and Tourist", which provided instruction on the manipulation of the newest forms of photographic apparatus and materials.

In 1883 D. H Cussons & Company published the "The Amateur's First Handbook: A Complete Guide and Instructor in the Art and Practice of Modern Dry-plate Photography, Illustrated with Woodcuts" by author J. H. T. Ellerbeck.

In approximately 1887 the company was no longer in business.

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